Explore the genes we test
Genes
Methylation Genes & Variants
Explore genes and genetic variants involved in methylation, nutrient metabolism, neurotransmitter activity, and cellular function.
Select a gene below to learn what it does and how specific variations may influence your wellness.
AHCY
Adenosylhomocysteinase
Helps break down S-adenosylhomocysteine (SAH), supporting homocysteine metabolism and methylation reactions.
Homocysteine
Detoxification
COMT
Catechol-O-Methyltransferase
Helps break down catecholamines such as dopamine, norepinephrine, and epinephrine through methylation.
Anxiety
Stress Response
FUT2
Fucosyltransferase 2
Adds fucose to glycans and influences secretor status, mucosal glycans, and interactions with the gut microbiome.
Gut Health
Inflammatory Bowel Disease
MTHFR
Methylenetetrahydrofolate Reductase
The A1298C variant can affect MTHFR activity and may influence folate-dependent methylation pathways.
Folate metabolism
Heart Health
MTR
Methionine Synthase
Uses vitamin B12 and 5-MTHF to help convert homocysteine to methionine, supporting the methylation cycle.
Vitamin B12
Cognition
MTRR
Methionine Synthase Reductase
Helps reactivate methionine synthase by maintaining its vitamin B12 cofactor in an active form.
B12 Deficiency
Fatigue
SHMT1
Serine Hydroxymethyltransferase 1
Transfers one-carbon units from serine into folate metabolism and supports the interconversion of serine and glycine.
DNA Synthesis
Folate Metabolism
TCN2
Transcobalamin II
Carries vitamin B12 in the bloodstream and supports delivery of the vitamin to cells for cellular use.
B12 Transport
Absorption
VDR
Vitamin D Receptor
Acts as a receptor for active vitamin D and regulates gene expression involved in calcium balance and other cellular functions.
Immunity
Gene regulation